The Best Dog Anxiety Medication

Just like people, dogs can experience anxiety and for a variety of different reasons. Common causes for anxiety in dogs include separation, trips to the vet, strangers, or loud noises like thunderstorms and fireworks. Some dogs are just prone to anxiety without particular triggers, though older dogs, ill dogs, and dogs of certain breeds may be especially likely to become anxious. And anxiety in dogs can cause anxiety in owners because they’re not sure how to help their dog that is so clearly upset. Fortunately, there are solutions.

We reviewed dozens of dog anxiety medications to identify the best of the best. We looked at ingredients, dosage and container size, administration method, and reviews from real customers to narrow down the options.

Best Dog Anxiety Medication Overall
Ready Pet Go! Calming Treats for Dogs
Ready Pet Go! Calming Treats for Dogs contain a bunch of ingredients proven to help calm and relax dogs but also have a great flavor that dogs love, making them the obvious choice for our top pick.

Our top pick and clear winner is Ready Pet Go! Calming Treats for Dogs. These dog treats have a bacon and cheese flavor that dogs love, but also contain proven ingredients like L-theanine, L-tryptophan, thiamine, and chamomile to help calm your anxious dog.

The 5 Top-Rated Dog Anxiety Medications

Editor's PicksBrandRating
Best Dog Anxiety Medication OverallReady Pet Go! Calming Treats for Dogs4.7
Best Liquid Dog Anxiety MedicationHempet Pet Hemp Oil4.6
Best Budget Dog Anxiety MedicationZesty Paws Hemp Elements Calming NutraStix Dental Sticks4.4
Best Natural Anxiety Medication for DogsHelopssa Hemp Calming Treats for Dogs4.6
Best Calming Treats for DogsFurroLandia Hemp Calming Treats for Dogs4.4

*Ratings are from Amazon and may change over time.

Best Dog Anxiety Medication Overall: Ready Pet Go! Calming Treats for Dogs

Our top pick is Ready Pet Go! Calming Treats for Dogs. They contain a comprehensive list of ingredients that help lower stress, reduce fear and aggression, and support calm behavior and a relaxed temperament. This includes treating not just anxiety, but also hyperactivity and related symptoms like jumping and barking in overexcitable dogs.

These ingredients include hemp powder, valerian root, chamomile, L-theanine, L-tryptophan, thiamine, magnesium, passion flower, and ginger root. However, at the same time, it also has a tasty bacon and cheese flavor that your dog will find irresistible. This means that not only do the ingredients themselves help handle anxiety but that since your dog will also love them, giving your dog these treats whenever they experience an anxiety trigger can help them create positive associations with the thing that causes their anxiety, which in turns helps to prevent that trigger from causing them anxiety in the future.

In addition, these calming treats are made in the USA at an FDA facility, are third-party lab tested, and contain no artificial ingredients, so you can feel good about the safety and quality of what you’re giving to your pup.

Ready Pet Go! Calming Treats for Dogs Key Features:

  • Comprehensive list of active ingredients
  • Appealing bacon and cheese flavor
  • Relieves anxiety and hyperactivity
  • Third-party lab tested
  • No artificial ingredients
  • Made in the US

Best Liquid Dog Anxiety Medication: Hempet Pet Hemp Oil

Liquid Dog Anxiety Medication
Hempet Pet Hemp Oil
Hempet Pet Hemp Oil doesn’t just relieve anxiety, it also promotes healthy skin, appetite, metabolism, and joints.

Hempet Pet Hemp Oil is comprised of only pure organic hemp oil, which naturally contains omega-3, 6, and 9 fatty acids that can help relieve dog anxiety and aggression. However, anxiety isn’t the only benefit of hemp oil. It can also relieve dry and irritated skin, improve appetite and metabolism and even promote joint health by improving mobility and reducing pain since it’s a natural anti-inflammatory. This makes hemp oil a great choice for dogs with multiple issues, especially older dogs since they’re more at risk for all of these issues or for multi-pet homes since it can be used to treat multiple conditions across multiple pets. It’s even safe for diabetic pets and can also be used for cats as well as dogs.

The liquid formula and included dropper makes it easy to mix with your dog’s regular food for administration that’s easy, stress-free for both you and your dog. It’s also made in the US from high-quality ingredients, is FDA approved, is vet-recommended, meets international pet safety standards, and has been carefully and thoroughly tested to ensure that it’s safe and effective for pets without dangerous side effects.

Hempet Pet Hemp Oil Key Features:

  • Pure organic hemp oil
  • Easy to administer
  • Also promotes skin and joint health and improves appetite and metabolism
  • Safe for dogs and cats
  • Made in the US
  • Meets FDA and international safety standards

Best Budget Dog Anxiety Medication: Zesty Paws Hemp Elements Calming NutraStix Dental Sticks

Best Budget Dog Anxiety Medication
Zesty Paws Hemp Elements Calming NutraStix Dental Sticks
Zesty Paws Hemp Elements Calming NutraStix Dental Sticks help your dog relax without forcing you to break the bank.

If you are looking for a way to help relieve your dog’s anxiety but can’t or don’t want to spend a lot, then you can’t go wrong with Zesty Paws Hemp Elements Calming NutraStix Dental Sticks. They contain numerous natural, holistic ingredients that are known to calm and relax dogs, including chamomile, valerian root, magnesium citrate, hemp extract, melatonin, and L-theanine. Specifically, they contain Suntheanine, which is a proprietary pure and GRAS-designated form of L-theanine which stimulates the canine brain to encourage relaxation without drowsiness. All of these ingredients can help relieve anxiety, as well as aggression and hyperactivity.

These ingredients are delivered in the form of a dental chew. Chewing can help further relieve anxiety as well as distract dogs from the source of their anxiety, but it also supports oral hygiene, dental health, and fresh breath. In addition to the relaxing, calming ingredients listed above, these dental chews also contain, taurine, kelp, and peppermint oil, which further promote dental health and fresh breath.

Zesty Paws uses only tasty and top quality ingredients from the industry’s best suppliers to ensure a safe, healthy product that dogs will enjoy.

Zesty Paws Hemp Elements Calming NutraStix Dental Sticks Key Features:

  • Chewing helps relieve anxiety and distract dogs
  • Includes a variety of calming, relaxing ingredients
  • Also promotes oral hygiene, dental health, and fresh breath
  • Made from only high-quality ingredients
  • Peppermint flavor
  • Available in 12 and 25 ounce packages

Best Natural Anxiety Medication for Dogs: Helopssa Hemp Calming Treats for Dogs

Best Natural Anxiety Medication for Dogs
Helopssa Hemp Calming Treats for Dogs
Helopssa Hemp Calming Treats for Dogs are a natural way to reduce your dog’s anxiety.

Our next pick, Helopssa Hemp Calming Treats for Dogs, is an excellent, 100% natural option for helping to alleviate your dog’s anxiety. They’re made in the United States and contain safe, soothing natural ingredients like hemp oil, chamomile extract, passion flower, valerian extract, ginger, turmeric, and L-tryptophan that work together to help your dog relax and stay that way. These calming treats can be used for car rides, trips to the vet, separation anxiety, thunderstorms, and more. And like our pick for the best liquid dog anxiety medication, Hempet Pet Hemp Oil, the hemp oil in these Helopssa Calming Treats for Dogs means that not only do they help with anxiety, they also promote joint health as well.

What they don’t contain is grain, gluten, soy, corn, or sugar. After all, you’re trying to help your dog by relieving their anxiety so why would you want a calming treat that includes ingredients that aren’t good for them? These calming treats can be used for dogs of all ages and sizes, and they have a duck flavor that dogs find delicious. Each package contains 180 chews.

Helopssa Hemp Calming Treats for Dogs Key Features:

  • Completely natural
  • Contains several active ingredients
  • Also promotes joint health
  • No grain, gluten, soy, corn, or sugar
  • Duck flavor
  • 180 chews

Best Calming Treats for Dogs: FurroLandia Hemp Calming Treats for Dogs

Best Calming Treats for Dogs
FurroLandia Hemp Calming Treats for Dogs
FurroLandia Hemp Calming Treats for Dogs support anxiety relief but taste just like a treat, so they’re easy to give to your dog.

Rounding out our list of the top five dog anxiety medications is FurroLandia Hemp Calming Treats for Dogs. It’s made with safe, natural, and effective ingredients like hemp oil, valerian extract, hemp seed powder, L-tryptophane, chamomile extract, and passion flower for a total of 74 organic minerals to reduce stress and promote general health. On the other hand, FurroLandia Hemp Calming Treats don’t contain soy, corn, hormones, dairy, sugar, grain, preservatives, or genetically modified organisms. They do, however, have a yummy bacon flavor that your dog will go crazy for.

These soft chews can be given to dogs big and small and each package contains approximately 170 soft chews, so the jar should last you for a while. FurroLandia Hemp Calming Treats are safe for daily use to help keep a frequently anxious dog relaxed or can be given just as needed to help relax a dog when it’s experiencing an anxiety trigger. These calming treats are made in the United States at an FDA registered facility and come with a 100% satisfaction guarantee.

FurroLandia Hemp Calming Treats for Dogs Key Features:

  • Made from natural ingredients
  • Several active ingredients for comprehensive anxiety support
  • No soy, corn, hormones, dairy, sugar, grain, preservatives or GMOs
  • Bacon flavor
  • Approximately 170 chews

Who Should Buy Dog Anxiety Medication

Any owner of a dog who suffers from anxiety may want to consider anxiety medication. This includes dogs that experience anxiety on a daily or near-daily basis or dogs that experience infrequent but severe anxiety. Anxiety medications can help to relieve that anxiety and dramatically improve an anxious dog’s quality of life. The most effective dog anxiety medications require a prescription from a vet, but these supplements can still go a long way to help, especially for dogs with less severe anxiety. However, you should always talk to your vet before giving your pet a new medication or supplement.

Not sure if your dog is experiencing anxiety or not? Symptoms of anxiety include aggression, drooling, panting, depression, restlessness, pacing, eliminating waste indoors despite being housebroken, destructive or compulsive behaviors, and excessive barking and other vocalization. If your dog is showing these symptoms, talk to your vet about whether or not they might be suffering from anxiety. In addition, keeping a record of what’s going on when they display these symptoms, as well as what happened beforehand, can help you identify the cause of your dog’s anxiety.

If your dog’s anxiety manifests as potty accidents, you may be interested in The Best Pet Carpet Cleaners.

Best Dog Anxiety Medication Overall
Ready Pet Go! Calming Treats for Dogs
Ready Pet Go! Calming Treats for Dogs contain a bunch of ingredients proven to help calm and relax dogs but also have a great flavor that dogs love, making them the obvious choice for our top pick.

Important Features to Consider

A dog anxiety medication should have a few important features. Here’s what to consider when selecting an anxiety medication for your dog:

  • Ingredients. You want natural ingredients that have been proven to be safe and effective for dogs with anxiety. Synthetic anxiety treatments can be effective, but will typically require a prescription from your vet and for good reason: while these medications are effective, they should only be used under the supervision of a veterinary professional. Ingredients you should look for include chamomile, L-tryptophan, L-theanine, and valerian.
  • Dosage size. You’ll want to check the dosage and make sure it’s a reasonable size for your dog. For example, maybe it would be difficult to measure a dosage small enough for your Chihuahua or perhaps your Great Dane would require most of the bottle for each dose.
  • Container size. Similarly, you don’t want to have to re-purchase constantly, so make sure you’ll get more than a few doses per container. You don’t want to look at just the size of the bottle though. A smaller bottle of medication may still contain more doses if the medication is more concentrated than one in a larger bottle.
  • Administration method. Dog anxiety medications come in a lot of different forms and each is best for a different situation. Liquid dog anxiety medications can easily be mixed into dog food, especially wet food. Many anxiety pills for dogs are flavored in a way that dogs will enjoy, but still have the look and texture of a pill. Finally, calming treats for dogs contain ingredients that help with anxiety, but look and taste like regular dog treats.

Frequently Asked Questions

What is dog anxiety medication and how does it work?

A dog anxiety medication contains active ingredients that help reduce or eliminate anxiety symptoms by helping your dog to feel calm and relaxed. They may be given regularly to prevent anxiety or as needed when anxiety occurs. They also come in a variety of forms, including pills, liquids, and treats.

Does my dog need anxiety medication?

If your dog shows symptoms like panting, shaking, aggression, excessive vocalization, eliminating waste indoors despite being housebroken, Training and counter-conditioning are generally the first line of defense for helping deal with anxiety in dogs, but if that doesn’t work, anxiety medication may be the solution. Your vet can help you determine whether or not an anxiety medication is the right choice for your dog.

How much Benadryl can you give a dog for anxiety?

Diphenhydramine, which is sold for humans under the name brand Benadryl, is a dog-safe option for anxiety that you can give your dog in a pinch. If you’ve ever taken this medication, you know it can make you feel relaxed and sleepy. That same effect is what helps dogs with anxiety.

The rule of thumb for determining an appropriate dose for a dog is up to one mg per pound of body weight, so a 10-pound dog can take 10 mg of Benadryl, while a 50-pound dog can take 50 mg. However, you should always talk to your vet before giving your dog any medication. You may also want to start with a lower dosage and give your dog more up to a mg per pound of body weight if they still show signs of anxiety after the initial dosage.

How can I ease my dog’s anxiety?

Dog anxiety is one way to ease dogs’ anxiety, but it’s not the only way, you can also try training and desensitization, music, compression wraps, certain pheromones, and even massages to help relax and calm your anxious dog.

Other Dog Anxiety Medications We Reviewed

Best Dog Anxiety Medication Overall
Ready Pet Go! Calming Treats for Dogs
Ready Pet Go! Calming Treats for Dogs contain a bunch of ingredients proven to help calm and relax dogs but also have a great flavor that dogs love, making them the obvious choice for our top pick.

We looked at 20 other dog anxiety medications. Even though they didn’t make our 5 best anxiety medications for dogs list, they’re the best of the rest and each is still a great option for your dog. The information you’ll need to compare each one is included with the listing.

Anxiety Pills for Dogs


Calmatrol Pet OTC Dog Separation Anxiety & Calming Meds

Calmatrol Pet OTC Dog Separation Anxiety & Calming Meds

Calmatrol uses the same active ingredient as Benadryl, diphenhydramine HCI, but in dog-sized gel cap doses.

Key Features:

  • Available in doses for dogs 26-50 pounds and for dogs 51-100 pounds
  • Relieves anxiety without lethargy
  • Clinically tested and well understood active ingredient

Cost: $25

NaturVet Quiet Moments Calming Aid Plus Melatonin

NaturVet Quiet Moments Calming Aid Plus Melatonin

The active ingredients in these tablets are time-released to help keep dogs calm for hours.

Key Features:

  • Contains chamomile flower, passion flower, thiamine mononitrate, ginger, L-tryptophan, and melatonin
  • Time-released
  • Available in 30 and 60 tablet bottles

Cost: $15

Nutrition Strength Dog Anxiety Relief Supplement

Nutrition Strength Dog Anxiety Relief Supplement

This dog anxiety pill contains a proprietary blend of valerian, chamomile, and passionflower, plus L-tryptophan, and comes with a 365-day money-back guarantee.

Key Features:

  • Specially formulated for the most effective blend of ingredients
  • Environmentally-friendly ingredients and production process
  • Organic, non-GMO, and gluten-free

Cost: $40

Particular Paws Dog Calming Aid

Particular Paws Dog Calming Aid

This anxiety pill contains ginger to help support the sensitive stomach that can accompany anxiety.

Key Features:

  • All-natural
  • Time-release
  • Contains 60 chewable tablets

Cost: $25

ProSense Anti-Stress Calming Tablets for Dogs

ProSense Anti-Stress Calming Tablets for Dogs

These chewable tablets contain antioxidants to help boost the immune system, which can be suppressed by anxiety.

Key Features:

  • Supports immune health
  • Contains 60 chewable tablets
  • Chamomile, ginger root, and valerian root help calm dogs

Cost: $5

Calming Treats for Dogs

Bingo Pet Products Organic Calming Treats for Dogs

Bingo Pet Products Organic Calming Treats for Dogs

These soft chews include common stress-relieving ingredients, but also a few not found in most other dog anxiety medications, such as inositol, GABA, and skullcap.

Key Features:

  • Peanut butter flavor
  • Available in a 120 count standard pack and a 5 count sample pack
  • Bingo Pet Co. donates a portion of each purchase to animal shelters across North America

Cost: $25

Goodgrowlies Calming Hemp Treats for Dogs

Goodgrowlies Calming Hemp Treats for Dogs

These calming treats include high concentrations of each active ingredient for maximum potency and effectiveness.

Key Features:

  • Good for dogs of all breeds and sizes
  • Contains valerian root, organic hemp seed oil, chamomile powder, L-tryptophan, organic passion flower, and organic ginger root powder
  • 120 soft chews

Cost: $25

Legitpet Calming Hemp Treats For Dogs

Legitpet Calming Hemp Treats For Dogs

These calming dog treats contain organic chamomile, hemp, and valerian root to soothe your dog while also being gentle on their stomach.

Key Features:

  • Duck flavored
  • No corn, dairy, soy, or artificial ingredients
  • 120 soft chews

Cost: $25

Moe’s Happy Hemp Calming Bites

Moe's Happy Hemp Calming Bites

These calming treats don’t just reduce anxiety, they also support joint, skin, nail, and coat health.

Key Features:

  • Contains organic hemp protein powder, thiamine B1, organic chamomile, L-tryptophan, valerian root, and L-theanine
  • Each purchase supports National Mill Dog Rescue
  • 120 soft chews

Cost: $30

NaturVet Hemp Quiet Moments Calming Aid for Dogs Plus Hemp Seed

NaturVet Hemp Quiet Moments Calming Aid for Dogs Plus Hemp Seed (1)-min

Use these calming dog treats daily or just when your pet encounters an anxiety-provoking stimulus.

Key Features:

  • Contains eight different active ingredients for comprehensive anxiety management
  • Wheat-free
  • Available in packages of 60 and 180 soft chews

Cost: $20

Pawesome Hemp Calming Treats for Dogs

Pawesome Hemp Calming Treats for Dogs

These calming treats contain several different active ingredients, but no soy, corn, dairy, artificial flavoring, preservatives, sugar, hormones, or GMOs.

Key Features:

  • 100% natural
  • Duck and bacon flavors
  • Not processed or cooked in order to maintain the integrity and potency of the ingredients

Cost: $25

Pet Parents USA Dog Calming Treats

Pet Parents USA Dog Calming Treats

On top of the anxiety-reducing ingredients, these calming treats also contain nutrient-rich ingredients like chicken, sweet potatoes, tomatoes, and carrots.

Key Features:

  • Soothes anxiety without causing drowsiness
  • Promotes a balanced mood
  • Contains approximately 90 soft chews

Cost: $30

Petaxin Calming Treats for Dogs

Petaxin Calming Treats for Dogs

Petaxin Calming Treats for Dogs are another great natural option without corn, wheat, or other grains.

Key Features:

  • Contains organic chamomile, organic passion flower, organic ginger root, L-tryptophan, and valerian root
  • 120 soft chews
  • Bacon flavor

Cost: $30

Pets Are Kids Too Premium Pet Calming Bites

Pets Are Kids Too Premium Pet Calming Bites

These calming pet treats are a safe, natural, and effective way to reduce anxiety in dogs.

Key Features:

  • Peanut butter and bacon flavored
  • 90 soft chews
  • Reduces anxiety and hyperactivity

Cost: $30

Premium Care Calming Treats for Dogs

Premium Care Calming Treats for Dogs

These calming treats contain chamomile extract, ginger root, hemp seed powder, valerian extract, hemp oil, L-tryptophane, and passion flower.

Key Features:

  • Reduce anxiety, aggression, and hyperactivity
  • Duck flavored
  • 120 soft chews

Cost: $30

VetriScience Composure Pro Bite Size Chews

VetriScience Composure Pro Bite Size Chews

All VetriScience products, including these calming treats, are veterinarian formulated so you know that they’re safe and effective.

Key Features:

  • Suitable for cats and dogs
  • Chicken liver flavor
  • 60 chews

Cost: $30

Liquid Dog Anxiety Medications

Kinpur Natural Hemp Oil

Kinpur Natural Hemp Oil

Kinpur Natural Hemp Oil is good for not just anxiety, but also immunity, appetite, and joint health.

Key Features:

  • Suitable for cats and dogs of all sizes
  • Appropriate for daily use
  • Contains 10,000mg

Cost: $15

Licks Dog Calming Supplements

Licks Dog Calming Supplements

Most liquid dog anxiety medications contain just a single ingredient, but this one includes organic chamomile, tryptophan, L-theanine, organic eleuthero root, and organic ashwagandha root in each liquid dose.

Key Features:

  • Multiple calming ingredients in each individually packaged dose
  • Beef flavor
  • Takes effect in only 30 to 60 minutes

Cost: $15

Licks Little Zen Calming Treats for Small Dogs

Licks Little Zen Calming Treats for Small Dogs

These are the same as the previous recommendation but packaged in smaller individual doses for smaller dogs and with a roasted chicken flavor.

Key Features:

  • Multiple calming ingredients in each individually packaged dose
  • Roasted chicken flavor
  • Takes effect in only 30 to 60 minutes

Cost: $30

Mix Rx Hemp Oil for Pets

Mix Rx Hemp Oil for Pets

If the natural taste puts your dog off of other hemp oils, this peanut butter flavored option may be just what you need.

Key Features:

  • Peanut butter flavor
  • Also promotes joint, cardiovascular, and neurological health
  • Two 1000 mg bottles

Cost: $10

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